Cross-talk Between Nitrate-Nitrite-NO and NO Synthase Pathways in Control of Vascular NO Homeostasis
نویسندگان
چکیده
منابع مشابه
Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis.
Nitrite represents a bioactive reservoir of nitric oxide (NO) that may modulate vasodilation, respiration and cytoprotection after ischemia-reperfusion injury. Although nitrite formation is thought to occur via reaction of NO with oxygen, this third-order reaction cannot compete kinetically with the reaction of NO with hemoglobin to form nitrate. Indeed, the formation of nitrite from NO in the ...
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NO generated from L-arginine by NO synthases (NOSs) in the endothelium and in other cells plays a central role in several aspects of vascular biology. The biological activity of NO is acutely terminated by oxidation to nitrite and nitrate, and these compounds have long been considered only as inert end-products of NO. However, this dogma is now being challenged because recent research convincin...
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PURPOSE Nitric oxide formation by nitric oxide synthase (NOS) has been implicated in vascular injury and retinal neovascularization during oxygen-induced retinopathy. However, the role of NOS in normal retinal vascular development and growth has not been studied. The purpose of these experiments was to characterize the expression of NOS in relation to vascular development and to determine the e...
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Endothelial production of nitric oxide (NO) is critical for vascular homeostasis. Nitrite and nitrate are formed endogenously by the stepwise oxidation of NO and have, for years, been regarded as inactive degradation products. As a result, both anions are routinely used as surrogate markers of NO production, with nitrite as a more sensitive marker. However, both nitrite and nitrate are derived ...
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The pivotal role of chronic inflammation in the pathogenesis of atherosclerosis and aortic aneurysm is now firmly established.1 Atherosclerotic lesions usually develop at branch points in arteries with abnormal shear stress. Risk factors such as hypercholesterolemia, hypertension, and cigarette smoke, among others, promote injury to the vascular endothelium, resulting in the infiltration of leu...
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2015
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2013.5481